Exim : 451-The server has reached its limit for processing requests from your host.n451 Please try again later.

451-The server has reached its limit for processing requests from your host.n451 Please try again later.

its probably exim's ratelimiting, add your servers IP's to the whitelist in WHM > Exim Configuration

Also check the value of the 'Maximum Emails a Domain Can Send In 1 Hour' value in WHM > Tweak Settings

retry time not reached for any host after a long failure period

exim_tidydb -t 10m /var/spool/exim retry
exim_tidydb -t 10m /var/spool/exim wait-remote_smtp